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The Combosyn, Inc., the publisher of CompuSyn software [1], which was set up by Dr. Dorothy Chou in 2005 with purpose of promoting the pharmacodynamic research and simple computerized analytical simulation using the median-effect principle of the mass-action law [2,3] and its combination index theorem [3,4].

The unique mathematical system analysis of the mass-action law (MAL) for dose-effect dynamics during 1966-1976 led to the discovery of the median-effect equation (MEE) as the unified biodynamics, pharmacodynamics and bioinformatics general principle (BD/PD/BI). The parameter m is dynamic-order signifying shape of dose-effect curve; Dm is the median-effect dose signifying potency, the universal reference-point and the common-link for different dynamic orders. The dynamics of the multiple entities interactions dynamics resulted in the general combination index equation (CIE), algorithm, and computer simulation which quantitatively determine Synergism (CI 1) automatically.

As of November 2022, the MAL-MEE/CIE theory has been cited over 21,350 times in over 1,469 scientific journals covering pharmacology, cancer research, biochemistry, molecular, cell biology and genetics, drug evaluation and therapeutics design, toxicology, agricultural, marine, environmental and food sciences. Its applications encompass broad spectrum of biomedical and other sciences; and the subjects include drugs, chemicals, biologicals, regardless of units, mode or mechanism of actions and the physical states. Recently, the applications of MAL-PD/BD/BI and CI have been extended to radiation, signaling, photo-dynamics, thermodynamics, UV and microwave, as well as the anti-microbial, anti-HIV, anti-SARS-CoV-2 drug evaluations. Currently the most widely used aspects are interaction dynamics of drug-drug or drug-entity, using the CI quantitative computer simulations; and single drug or single entity for the MAL-basic dynamic parameters, m (shape, or dynamic-order) and Dm (potency, or dynamic order common--link), for digital determination of PD basic properties and for the unified ranking of drugs or entities.

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ATTENTION: Beginning in January 2021, these files are available as free downloads. Please note that these are large files and can take time to download. The last two years of files (CY2019 and CY2020) are also available to download for free. Please see the following link for these downloads: -statistics-data-systems/prescription-drug-plan-formulary-pharmacy-network-and-pricing-information-files

Overview of File: The Prescription Drug Plan Formulary, Pharmacy Network, and Pricing Information Files contain formulary, pharmacy network, and pricing data for Medicare Prescription Drug Plans and Medicare Advantage (MA) Prescription Drug Plans (with the exception of employer and Program of All-Inclusive Care for the Elderly plans). These non-identifiable files are available on a monthly and a quarterly basis and are comprised of the following tables:

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Download ZEN lite, your free copy of the powerful ZEN microscopy software. Use ZEN lite as a viewer for your CZI files or other standard file types. Perform image acquisition or fundamental image analysis and processing tasks.

Please note: ZEN lite is the free, unlicensed edition of ZEN. Once ZEN has been downloaded and installed, ZEISS Microscopy Installer will check your ZEN license and, if you don't have one, will default you to ZEN lite.

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If you have set your Mac to allow apps only from the App Store and you try to install an app from elsewhere, your Mac will say that the app can't be opened because it was not downloaded from the App Store.*

The above download links will direct you to the Oracle eDelivery web site where you will complete your download. You will be prompted to log in with your Oracle Single Sign On account, select a platform to download, and accept the appropriate license agreement to continue. Any additional technical resources, documentation, community resources, and related product information can be found below if applicable. For more information about eDelivery or if you find yourself unfamiliar with the new site, please take a moment to walk through the Oracle Software Delivery Cloud Upgrade Tour in the FAQ:

Our Medical Information team of dedicated pharmacists, physicians, and associates creates the essential clinical content for epocrates. Our team strives to provide information that is objective, accurate, current, concise, and clinically relevant.Learn how we develop our drug content

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Images and other uploaded media are available from mirrors in addition to being served directly from Wikimedia servers. Bulk download is (as of September 2013) available from mirrors but not offered directly from Wikimedia servers. See the list of current mirrors. You should rsync from the mirror, then fill in the missing images from upload.wikimedia.org; when downloading from upload.wikimedia.org you should throttle yourself to 1 cache miss per second (you can check headers on a response to see if was a hit or miss and then back off when you get a miss) and you shouldn't use more than one or two simultaneous HTTP connections. In any case, make sure you have an accurate user agent string with contact info (email address) so ops can contact you if there's an issue. You should be getting checksums from the mediawiki API and verifying them. The API Etiquette page contains some guidelines, although not all of them apply (for example, because upload.wikimedia.org isn't MediaWiki, there is no maxlag parameter).

Unlike most article text, images are not necessarily licensed under the GFDL & CC-BY-SA-3.0. They may be under one of many free licenses, in the public domain, believed to be fair use, or even copyright infringements (which should be deleted). In particular, use of fair use images outside the context of Wikipedia or similar works may be illegal. Images under most licenses require a credit, and possibly other attached copyright information. This information is included in image description pages, which are part of the text dumps available from dumps.wikimedia.org. In conclusion, download these images at your own risk (Legal)

Before starting a download of a large file, check the storage device to ensure its file system can support files of such a large size, and check the amount of free space to ensure that it can hold the downloaded file. 2b1af7f3a8